Audrey C. Brumback

The paper uses nanophotonic methods to observe sequential ligand binding to a cyclic nucleotide-gated ion channel at single-molecule resolution, revealing cooperative binding and intermediate states.

The paper investigates the effect of the GABAA receptor α4 subunit variant Ile114Asn on membrane expression when combined with β3 and δ subunits, finding reduced maximal GABA-elicited currents.

This study develops a novel mouse model with Purkinje cell-specific Scn1b deletion, revealing cerebellar dysfunction and associated neurological impairments without early mortality.

This study identifies differences in HCN channel activity across mediodorsal thalamus subnuclei, linking these differences to distinct intrinsic oscillatory properties and cellular resonance.

This study shows that Fmr1 knockout in mice reduces HCN channel activity in mediodorsal thalamocortical neurons, leading to delayed rebound spike timing and potential disruptions in thalamocortical circuitry.

This study identifies two distinct subnuclei in the mediodorsal thalamus that project to the medial prefrontal cortex, showing differences in physiology and morphology.