Integrative Genetic and Single-Cell Analysis Reveals Macrophages as Key Mediators Linking Aging and Osteoporosis
Xin Li, Meng-Yuan Yang, Si-Rui Gai, Peng Wei, Zeng-Hui Gu, Mingyu Han, Yue-zhou Wu, Jiasheng Yu, Wang-Jun Chen, Zhen-Rui Liao, Jia-Xuan Gu, Jia-Dong Zhong, Pianpian Zhao, Ke Zhu, CL Cheung, , Hou-Feng Zheng
The paper identifies macrophages as key mediators linking aging and osteoporosis using genetic and single-cell analyses, revealing TGFB1 and HNRNPUL1 as critical regulators.
medRxiv · Sep 13, 2026 · PreprintGenetic & Genomic Medicine