Peng Wei

Integrative Genetic and Single-Cell Analysis Reveals Macrophages as Key Mediators Linking Aging and Osteoporosis

The paper identifies macrophages as key mediators linking aging and osteoporosis using genetic and single-cell analyses, revealing TGFB1 and HNRNPUL1 as critical regulators.

Lineage specifying transcription factors determine cell function by direct control of metabolism

The paper identifies lineage-specifying transcription factors that directly control metabolism to ensure cell function.

Semi-rational Engineering of Terminal Deoxynucleotidyl Transferase for High-efficiency Enzymatic de Novo DNA Synthesis

This paper engineers terminal deoxynucleotidyl transferase (TdT) to improve enzymatic DNA synthesis efficiency and scalability.

SUGP1 associates Y-box protein to regulate piRNA biogenesis in Bombyx mori

This study identifies SUGP1 as a key splicing factor in piRNA biogenesis in Bombyx mori, revealing its interaction with Y-box protein and dual role in piRNA maturation and transposon regulation.

CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection

This paper identifies CTHRC1 as a therapeutic target and serum biomarker for aortic dissection, showing it regulates VSMC phenotype and aortic integrity via the ERK1/2 pathway.