David Karasik

The paper identifies macrophages as key mediators linking aging and osteoporosis using genetic and single-cell analyses, revealing TGFB1 and HNRNPUL1 as critical regulators.

This study investigates the role of cped1 in zebrafish bone and lean mass, finding no significant effects on these traits despite loss of function.

This study performs GWAS on BMD traits and fracture risk using 30,000 UK Biobank samples, identifies novel loci, and prioritizes drug targets for osteoporosis prevention.

The paper introduces SEAD, an Asian reference panel that improves rare variant imputation and GWAS analysis, identifying a novel association between SNTG1 and hip BMD.

This study shows that stac3 knockout in zebrafish mimics early life lipid overload and muscle weakness seen in Native American myopathy.

This paper shows that wnt16 regulates spine and muscle morphogenesis in zebrafish through signals from notochord and dermomyotome, explaining its dual role in bone and muscle traits.

This study identifies 59 genome-wide significant loci for skull bone mineral density, including four novel loci, and links them to osteoporosis and craniofacial developmental defects.

This study identifies 15 genetic loci associated with muscle weakness in older adults through a large meta-analysis, revealing new pathways linked to aging and health outcomes.

The paper identifies novel lncRNAs in hypoxic zebrafish brain regions and links some to AD-related pathways and conserved functions.

This paper identifies 518 genetic loci associated with bone mineral density and fracture risk, validates causal genes in mice, and provides insights for osteoporosis drug development.

The paper analyzes genetic and environmental factors in Israeli kibbutzim to identify cardiometabolic trait associations and population structure.