Reduced SK channel control of mesolimbic dopamine neuron firing drives reward seeking adaptations in chronic pain
Jeremy M. Thompson, Robert D. Graham, Jeff P. Goff, Yu-Hsuan Chang, Vani Kalyanaraman, Chang S Xu, Mason R. Barrett, Hanyun Wang, Travis A Hage, Alex A. Legaria, Mengtong Liu, Rebecca George, Bryan A. Copits, Alexxai V. Kravitz, Meaghan C. Creed
The paper identifies impaired SK channel function in mesolimbic dopamine neurons as a mechanism driving reward seeking adaptations in chronic neuropathic pain.
bioRxiv · Oct 6, 2025 · PreprintNeuroscience