Sarbecovirus RBD indels and specific residues dictating ACE2 multi-species adaptiveness
Jun-Yu Si, Yuanmei Chen, Ye-Hui Sun, Mengxue Gu, Meiling Huang, Lulu Shi, Yu Xiao, Xiao Yi Yang, Qing Xiong, Chengbao Ma, Peng Liu, Zheng‐Li Shi, Huan Yan
This study identifies RBM indel types in sarbecoviruses and their impact on ACE2 receptor usage across species, revealing how specific residues and structural features influence tropism and adaptiveness.
Nature Communications · Oct 14, 2024Peer-reviewedMicrobiology