Convergent utilization of APN receptor by hedgehog merbecoviruses
Peng Liu, Qianhui Zhu, Jingyi Liu…·Huan Yan
The paper identifies hedgehog APN as a receptor for EriCoVs and shows convergent evolution in its utilization among merbecoviruses.
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Wuhan UniversityORCID 0000-0002-8766-9510Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Peng Liu, Qianhui Zhu, Jingyi Liu…·Huan Yan
The paper identifies hedgehog APN as a receptor for EriCoVs and shows convergent evolution in its utilization among merbecoviruses.
Peng Liu, Meiling Huang, Hua Guo…·Huan Yan
This paper develops a method to engineer customized viral receptors (CVRs) for various coronaviruses, enabling infection models for viruses lacking known receptors.
Jun-Yu Si, Yuanmei Chen, Ye-Hui Sun…·Huan Yan
This study identifies RBM indel types in sarbecoviruses and their impact on ACE2 receptor usage across species, revealing how specific residues and structural features influence tropism and adaptiveness.