Author

Mengzhe Shen

BGI Group (China)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Research Focus:software / tool· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Xun XuiD· 2 shared Antoni BeltraniD· 1 shared Ben LehneriD· 1 shared Bo Teng· 1 shared Chenglong LiangiD· 1 shared Chengwang Xie· 1 shared Chuang LiiD· 1 shared Chuanyu LiuiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Xun XuORCID

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Author profile →

2 papers

Recent·Most cited

Ultrahigh-Throughput Forster Resonance Energy Transfer-Activated Droplet Sorting for Terminator Polymerase Engineering

Hui Zhang, Qingqing Xie, Haoran Xu, Wei Li, Chuang Li, Liang Shen, Peiyi Wang, Xinjiang Yan, Xiang Li, Shiyue Zhou, Shitian Zhuo, Chuanyu Liu, Bo Teng, Yuliang Dong, Mengzhe Shen, , Xun Xu

This paper introduces a dual-channel FRET-based droplet sorting system to enhance terminator polymerase engineering, achieving 30-fold enrichment of active variants in a single round.

bioRxiv · Dec 20, 2025 · PreprintBiochemistry

Revolutionizing large-scale DNA synthesis with microchip-based massive in parallel synthesis system

Xiandi Zhang, X. L. Jiang, Yun Wang, Qingze Chen, Ruihong Zhang, Hao Jiang, Hu Zhang, Antoni Beltran, Weiya Yang, Chenglong Liang, Ning Chen, Yun Long Huang, Guqiao Ding, Chengwang Xie, Nanfeng Gao, , Yue Shen

This paper introduces a microchip-based DNA synthesis system that significantly improves DNA product concentration and simplifies downstream processes for large-scale gene synthesis.

bioRxiv · Oct 30, 2024 · PreprintSynthetic Biology