Spatial model predicts dispersal and cell turnover cause reduced intra-tumor heterogeneity
Bartlomiej Waclaw, Ivana Bozic, Meredith E Pittman, Ralph H Hruban, Bert Vogelstein, Martin A Nowak
The paper develops a spatial model showing that short-range cell migration and turnover explain reduced intra-tumor heterogeneity and rapid clonal expansion in cancers.
Nature · Sep 10, 2015Peer-reviewedCancer Biology