Author

Martin A Nowak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:phylogenetics / evolution· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Bert Vogelstein· 2 shared Ivana Bozic· 2 shared Alejandro ChaveziD· 1 shared Alison L Hill· 1 shared Alvin P Makohon-Moore· 1 shared Andrea L Smidler· 1 shared Bartlomiej Waclaw· 1 shared Charleston NobleiD· 1 shared

Activity by Year

2014-2016 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Bert Vogelstein

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Daisy-chain gene drives for the alteration of local populations

Charleston Noble, John Min, Jason Olejarz, Joanna Buchthal, Alejandro Chavez, Andrea L Smidler, Erika A DeBenedictis, George M Church, Martin A Nowak, Kevin M Esvelt

This paper introduces daisy-chain gene drives that can alter local populations without global spread, enabling ethical use and community control.

bioRxiv · Jun 7, 2016Synthetic Biology

Reconstructing phylogenies of metastatic cancers

Johannes G Reiter, Alvin P Makohon-Moore, Jeffrey M Gerold, Ivana Bozic, Krishnendu Chatterjee, Christine A Iacobuzio-Donahue, Bert Vogelstein, Martin A Nowak

This study introduces Treeomics, a tool that accurately reconstructs metastatic cancer phylogenies and disambiguates sequencing artifacts, showing high accuracy across varying sample conditions.

bioRxiv · Apr 11, 2016Cancer Biology

Spatial model predicts dispersal and cell turnover cause reduced intra-tumor heterogeneity

Bartlomiej Waclaw, Ivana Bozic, Meredith E Pittman, Ralph H Hruban, Bert Vogelstein, Martin A Nowak

The paper develops a spatial model showing that short-range cell migration and turnover explain reduced intra-tumor heterogeneity and rapid clonal expansion in cancers.

Nature · Sep 10, 2015Peer-reviewedCancer Biology

Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multi-drug resistance

Stefany Moreno-Gamez, Alison L Hill, Daniel I.S. Rosenbloom, Dmitri A. Petrov, Martin A Nowak, Pleuni Pennings

The paper models how imperfect drug penetration creates spatial monotherapy, accelerating multi-drug resistance evolution in infections.

bioRxiv · Dec 19, 2014Evolutionary Biology