Evaluating the impact of NPC1 SNPs on entry efficiency of Filovirus in vitro: agent-based model approach
Ju Seong Kim, Kwang Su Kim, Ayato Takada, Yusuke Asai, Shingo Iwami, Seungwoo Son, Mi Jin Lee
The paper uses an agent-based model to quantify how specific NPC1 SNPs affect filovirus entry efficiency in vitro, finding that D508N, P424A, and S425L reduce entry efficiency for both Ebola and Marburg viruses.
bioRxiv · Mar 13, 2025 · PreprintSystems Biology