Shingo Iwami

This study investigates how extrachromosomal DNA (ecDNA) copy numbers change during drug treatment, showing that resistant clones can actively reconfigure segregation behavior rather than relying on pre-existing clones.

This study models oseltamivir's effects on viral shedding and symptom outcomes in experimental influenza infections using clinical trial data, finding no significant antiviral efficacy or dose-dependent effects.

This study stratifies SARS-CoV-2 viral shedding patterns in saliva into three groups with distinct durations using a mathematical model and clustering, but finds no clear clinical or miRNA biomarkers explaining the differences.

This study shows that dopaminergic signaling via Dop1R2 modulates auditory sensory neuron responses in Drosophila females based on their mating status, affecting song response behavior.

This study identifies a myeloid bypass pathway that supports long-term HSC reconstitution by analyzing single-cell transplantation data with a mathematical model.

The paper uses an agent-based model to quantify how specific NPC1 SNPs affect filovirus entry efficiency in vitro, finding that D508N, P424A, and S425L reduce entry efficiency for both Ebola and Marburg viruses.

The paper analyzes longitudinal antibody titers post-vaccination to identify individuals at risk for breakthrough infections and identifies three population groups with distinct immune response patterns.

The paper introduces a required concentration index to rank antiviral efficacy of HCV drug combinations and shows multidrug treatments enhance activity but reduce genotype-specific efficacy.