Combined Checkpoint Inhibition Amplifies Post-Infarction Injury via T Cell-Mediated Macrophage Activation
Xingzhi Wang, Miaomiao Cai, Y Zhou, Mengyuan Feng, Peibin Chen, J ian-xing Zhang, Siqi Liu, Yajie Song, Cuige Zhu, Ailan Chen, Guoshuai Feng
This study shows that combined PD-1/CTLA-4 checkpoint inhibition worsens post-MI cardiac injury by promoting CD8+ T cell-driven macrophage activation through the JAK-STAT1 pathway.
bioRxiv · May 21, 2026 · PreprintImmunology