Siqi Liu

This study shows that combined PD-1/CTLA-4 checkpoint inhibition worsens post-MI cardiac injury by promoting CD8+ T cell-driven macrophage activation through the JAK-STAT1 pathway.

This study integrates proteogenomic analyses of esophageal squamous cell carcinoma to identify molecular subtypes and potential therapeutic strategies.

PepGo is a deep learning and tree search-based model for de novo peptide sequencing that outperforms existing methods by integrating Transformer networks with Monte Carlo Tree Search.

This study identifies 30 novel metabolite-gene associations in 34,394 Chinese pregnant women and finds pleiotropy and causal relationships between metabolites and diseases.

This study identifies ADGRA3 as a GPCR that promotes adipose thermogenesis through constitutive activity and the Gs-PKA-CREB axis, with hesperetin as a potential agonist for therapeutic obesity treatment.

The paper predicts meiosis-essential genes by analyzing dynamic proteomes from spermatogenesis-synchronized mice and validates four candidates using knockout models.

This paper standardizes a proteotype analysis workflow across multiple international sites to enable distributed, reproducible proteomic data generation for precision medicine.

This study analyzes cytokine dynamics in H7N9-infected patients with different outcomes, identifying predictors and a real-time prognosis model.

This study evaluates SWATH-MS across 11 labs, showing consistent detection and quantification of over 4,000 proteins with reproducible quantitative data.