Michael A Newton

CD3, CD28, TCRαβ expression and IL-2 production in a spontaneous glycosylphosphatidylinositol-deficient Jurkat T cell line

This study examines the effects of GPI-deficiency on TCR, CD3, CD28 expression and IL-2 production in a GPI-deficient Jurkat T cell line, finding altered surface receptor expression but no significant impairment in IL-2 production under direct pathway activation.

Spatial Autocorrelation Aware Resampling Improves Cell-Cell Interaction Inference in Spatial Transcriptomics Data

SOAAR improves cell-cell interaction inference in spatial transcriptomics by accounting for spatial autocorrelation, reducing false positives and identifying consistent immune signatures in cancer patients.