Michael A. Gaffield

Molecular layer disinhibition unlocks climbing-fiber-instructed motor learning in the cerebellum

The paper shows that suppressing molecular layer interneurons (MLIs) in mice enables climbing-fiber-mediated motor learning during the vestibulo-ocular reflex, even without performance errors.

Conversion of graded presynaptic climbing fiber activity into graded postsynaptic Ca2+ signals by Purkinje cell dendrites

The paper shows that Purkinje cell dendrites convert graded climbing fiber activity into Ca2+ signals, highlighting the inferior olive's role in generating signals for plasticity and learning.