Author

Michael C. Heinold

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Organism:human· 1

Frequent Co-Authors

Kortine KleinheinziD· 2 shared Matthias SchlesneriD· 2 shared Roland EilsiD· 2 shared Adam P. Butler· 1 shared Alex Buchanan· 1 shared Ana Mijalkovic Lazic· 1 shared André KahlesiD· 1 shared Andy CafferkeyiD· 1 shared

Activity by Year

2017-2017 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Kortine KleinheinzORCID

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2 papers

Recent·Most cited

ACEseq - allele specific copy number estimation from whole genome sequencing

Kortine Kleinheinz, Isabell Bludau, Daniel Hübschmann, Michael C. Heinold, Philip Reiner Kensche, Zuguang Gu, Cristina López, Michael Hummel, Wolfram Klapper, Peter Loof Møller, Inga Vater, Rabea Wagener, ICGC MMML-Seq project, Benedikt Brors, Reiner Siebert, , Matthias Schlesner

ACEseq estimates allele-specific copy numbers, tumor purity, ploidy, and homologous recombination deficiency scores from tumor whole-genome sequencing by combining GC-bias correction, replication-timing correction, and structural variant breakpoints.

bioRxiv · Oct 29, 2017 · PreprintBioinformatics

Large-Scale Uniform Analysis of Cancer Whole Genomes in Multiple Computing Environments

Christina K. Yung, Brian D. O’Connor, Sergei Yakneen, Junjun Zhang, Kyle Ellrott, Kortine Kleinheinz, Naoki Miyoshi, Keiran M. Raine, Romina Royo, Gordon Saksena, Matthias Schlesner, Solomon I. Shorser, Miguel Vazquez, Joachim Weischenfeldt, Denis Yuen, , Charles L. Short

The paper describes the PCAWG project's large-scale analysis of cancer whole genomes across multiple computing environments, producing validated consensus variants for downstream research.

bioRxiv · Jul 10, 2017 · PreprintGenomics