Chronic cold exposure induces plasticity of mitochondrial calcium uptake in beige and brown fat of UCP1-deficient mice.
Casandra G. Chamorro, Sachin Pathuri, Rebeca Acín‐Pérez, Michael Chhan, Madeleine G. Milner, Natalia V. Ermolova, Anthony E. Jones, Ajit S. Divakaruni, Linsey Stiles, Andrea Lynn Hevener, Zhenqi Zhou, Orian S. Shirihai, Yuriy Kirichok, Ambre M. Bertholet
This study shows that UCP1-deficient mice adapt to cold by increasing mitochondrial calcium uptake via MCU, enhancing thermogenesis without UCP1.
bioRxiv · Mar 18, 2026 · PreprintPhysiology