Elucidating synergistic dependencies in lung adenocarcinoma by proteome-wide signaling-network analysis
Mukesh Bansal, Jing He, Michael Peyton, Manjunath Kustagi, Archana Iyer, Michael J. Comb, Michael A. White, John Dorrance Minna, Andrea Califano
The paper infers protein kinase pathways in lung adenocarcinoma using phosphotyrosine data and validates them with SILAC assays, revealing novel substrates and synergistic drug responses.
PLoS ONE · Jan 7, 2019Peer-reviewedSystems Biology