Jing He

This study examines caudate nucleus aging across species and diseases, identifying shared and disorder-specific age-related changes in cell types and regulatory features.

The paper introduces DIMER, a framework for drug repurposing and virtual screening in Parkinson's disease, identifying 423 candidates and validating four in organoids.

The paper introduces CTACIT to fine-map neuropsychiatric regulatory variants by integrating conservation scores with cell type-specific open chromatin data across species.

The paper builds a multimodal atlas of medium spiny neurons in the primate striatum, identifying new subtypes and linking them to disease associations.

The paper identifies cell type-specific enhancers for the DLPFC in NHPs using single nucleus RNA-Seq and ATAC-Seq, validates them with AAV injections, and demonstrates functional expression in specific neuron types.

The paper uses phosphoproteomic time-series data and the VESPA algorithm to analyze drug resistance mechanisms in colon cancer cells, revealing adaptive signaling rewiring confirmed by CRISPRko assays.

The paper introduces SNAIL, a virus-based method using machine learning to design cell type-specific enhancer probes for targeted nuclear isolation and characterization.

The paper compares open chromatin regions in motor cortex subdivisions across primates and rodents to identify gene regulatory programs involved in the evolution of fine motor skills.

This study identifies molecularly distinct medium spiny neuron types in the primate striatum, revealing new subtypes associated with specific anatomical compartments and functional roles.

The paper infers protein kinase pathways in lung adenocarcinoma using phosphotyrosine data and validates them with SILAC assays, revealing novel substrates and synergistic drug responses.