Michael A. White

This study shows that sex chromosomes have a larger effect on gene expression in somatic tissues than gonadal sex, while gonadal sex has a larger effect in gonads, using threespine stickleback fish.

This paper identifies a Y-linked duplication of the anti-Mullerian hormone gene (amhy) as the primary sex determination gene in threespine stickleback, showing its necessity and sufficiency for male sex determination.

The paper uses single-cell RNA-seq to show no evidence of meiotic sex chromosome inactivation in threespine stickleback fish, suggesting MSCI is not conserved in teleosts.

The paper investigates cis-regulatory evolution on the Y chromosome of threespine stickleback, finding positive selection in enhancer regions and correlation with X-biased gametolog expression.

This study examines meiotic pairing and double strand break formation in threespine stickleback sex chromosomes, finding that they pair non-homologously and repair breaks similarly to autosomes.

The paper uses long-read RNA sequencing to identify sex-specific alternative splicing in threespine stickleback fish, revealing thousands of novel isoforms and refining gene annotations.

The paper improves the contiguity of the threespine stickleback genome using long-read sequencing, filling over 76% of gaps and enhancing contiguity five-fold.

The paper quantifies synaptonemal complex length in threespine stickleback fish and finds sexual dimorphism and population differences.

The paper examines fine-scale recombination landscapes in threespine stickleback fish populations, finding divergent hotspots and no strong PRDM9 association.

The paper infers protein kinase pathways in lung adenocarcinoma using phosphotyrosine data and validates them with SILAC assays, revealing novel substrates and synergistic drug responses.