Michael J. Williams

Nitroxoline-O-protected derivatives inhibit MetAP2 and activate ATF4 through mTORC1 to inhibit cancer cell growth

The paper synthesizes nitroxoline analogs that inhibit MetAP2 and activate ATF4 via mTORC1, showing anti-cancer effects in vitro.

Silylation of hydroxychloroquine enhances autophagy inhibition and antiproliferative activity in breast and pancreatic cancer cells

This paper shows that silylating hydroxychloroquine improves its autophagy inhibition and antiproliferative effects in cancer cells.