Author

Michael Kane

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Charles P. FulcoiD· 3 shared Drew T. BergmaniD· 3 shared Eric S. LanderiD· 3 shared Glen Munson· 3 shared J EngreitziD· 3 shared Joseph NasseriD· 3 shared Thouis R. JonesiD· 3 shared Tung H. NguyeniD· 3 shared

Activity by Year

2016-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Charles P. FulcoORCID

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Author profile →

4 papers

Recent·Most cited

Compatibility logic of human enhancer and promoter sequences

Drew T. Bergman, Thouis R. Jones, Vincent Liu, Layla Siraj, Helen Y. Kang, Joseph Nasser, Michael Kane, Tung H. Nguyen, Sharon R. Grossman, Charles P. Fulco, Eric S. Lander, J Engreitz

The paper measures enhancer-promoter compatibility in human cells using a high-throughput assay, finding a multiplicative model with some class-specific preferences.

bioRxiv · Oct 23, 2021 · PreprintGenetics

Genome-wide maps of enhancer regulation connect risk variants to disease genes

Joseph Nasser, Drew T. Bergman, Charles P. Fulco, Philine Guckelberger, Benjamin R. Doughty, Tejal A. Patwardhan, Thouis R. Jones, Tung H. Nguyen, Jacob C. Ulirsch, Heini M. Natri, Elle M. Weeks, Glen Munson, Michael Kane, Helen Y. Kang, Ang Cui, , J Engreitz

The paper uses the ABC Model to map enhancer-gene regulation across 131 cell types and tissues, linking GWAS variants to disease genes, particularly in IBD.

bioRxiv · Sep 1, 2020 · PreprintGenetics

Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations

Charles P. Fulco, Joseph Nasser, Thouis R. Jones, Glen Munson, Drew T. Bergman, Vidya Subramanian, Sharon R. Grossman, Rockwell Anyoha, Tejal A. Patwardhan, Tung H. Nguyen, Michael Kane, Benjamin R. Doughty, Elizabeth M. Perez, Neva C. Durand, Elena K. Stamenova, , J Engreitz

The paper introduces CRISPRi-FlowFISH to perturb enhancers and an Activity-by-Contact model to predict enhancer-gene regulatory connections.

bioRxiv · Jan 26, 2019 · PreprintGenetics

Neighborhood regulation by lncRNA promoters, transcription, and splicing

Jesse M. Engreitz, Jenna E. Haines, Glen Munson, Jenny Chen, Elizabeth M. Perez, Michael Kane, Patrick E. McDonel, Mitchell Guttman, Eric S. Lander

The paper investigates how lncRNA loci regulate neighboring genes and finds that transcription and splicing processes, not specific lncRNA transcripts, mediate this regulation.

bioRxiv · Apr 29, 2016 · PreprintMolecular Biology