Author

Layla Siraj

Broad InstituteORCID 0000-0002-3756-7495Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Eric S. LanderiD· 2 shared Thouis R. JonesiD· 2 shared Alexander V. GuseviD· 1 shared Alexandr BoytsoviD· 1 shared Caleb A. LareauiD· 1 shared Charles P. FulcoiD· 1 shared Christopher M. VockleyiD· 1 shared Daniel BerenzyiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenetics

Eric S. LanderORCID

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2 papers

Recent·Most cited

Functional dissection of complex and molecular trait variants at single nucleotide resolution

Layla Siraj, Rodrigo I. Castro, Hannah B. Dewey, Susan Kales, John C. Butts, Thanh Thanh L. Nguyen, Masahiro Kanai, Daniel Berenzy, Kousuke Mouri, Qingbo S. Wang, Petko P. Fiziev, Kristin Tsuo, Zachary Ryan McCaw, Sager J. Gosai, François Aguet, , Ryan Tewhey

This study functionally characterizes 221,412 trait-associated variants using MPRA in 5 cell types, identifying 12,025 regulatory variants and revealing widespread epistasis and non-TF mechanisms.

Nature · Feb 25, 2026Peer-reviewedGenetics

Compatibility logic of human enhancer and promoter sequences

Drew T. Bergman, Thouis R. Jones, Vincent Liu, Layla Siraj, Helen Y. Kang, Joseph Nasser, Michael Kane, Tung H. Nguyen, Sharon R. Grossman, Charles P. Fulco, Eric S. Lander, J Engreitz

The paper measures enhancer-promoter compatibility in human cells using a high-throughput assay, finding a multiplicative model with some class-specific preferences.

bioRxiv · Oct 23, 2021 · PreprintGenetics