Heini M. Natri

This study shows that targeting the TGFβ pathway improves CAR T cell efficacy in glioblastoma by enhancing antitumor activity and modulating the tumor microenvironment.

This study identifies SPP1+ macrophages as key drivers of resistance to CAR T therapy in solid tumors and shows that targeting SPP1 can overcome this resistance.

This study compares transcriptomic and immune profiles of HBV- and HCV-mediated HCC, finding convergence in tumor landscapes despite differences in adjacent tissue and highlighting sex sampling limitations.

This study identifies germline and somatic genetic effects on gene expression and patient outcomes in Multiple Myeloma using matched genotype and expression data from 607 patients.

The paper identifies cell-type-specific and disease-associated eQTL in the human lung using single-cell RNA-sequencing data from PF and unaffected donors.

The paper replicates and extends previous findings showing no parent-of-origin effects in Nasonia jewel wasps, instead finding species-of-origin effects using new data and analysis methods.

PopInf assigns genetic ancestry to samples with unknown origin using a reference panel, identifying discrepancies between reported race and inferred ancestry in TCGA liver cancer data.

The paper identifies Indonesia-specific eQTLs and methylQTLs linked to local ancestry and archaic introgression, showing their impact on gene regulation and hematological traits.

The paper uses the ABC Model to map enhancer-gene regulation across 131 cell types and tissues, linking GWAS variants to disease genes, particularly in IBD.

The paper analyzes DNA methylation and gene expression in Indonesian populations to show genetic ancestry, environmental influences, and immune-related differences across regions.

This study identifies sex-specific gene expression and eQTL differences in hepatocellular carcinoma, revealing distinct molecular mechanisms driving male and female HCC.