Altered Protein Phosphorylation in a Novel Midbrain Organoid Model for Bipolar Disorder
Katharina Meyer, Matthew Woodworth, Maria Carolina Bittencourt Gonçalves, Mi Yue, Hoor Al Jandal, Shad Morton, Michael Lewandowski, Ninning Liu, Eric S. Zigon, Patrick R.J. Fortuna, Mariana García-Corral, Bogdan Budnik, George McDonald Church, Jenny M. Tam
This study develops a midbrain organoid model for bipolar disorder using patient-derived hiPSCs, identifies dysregulated signaling pathways, and shows lithium reverses some abnormalities.
bioRxiv · Apr 1, 2025 · PreprintCell Biology