Author

Jenny M. Tam

Harvard UniversityORCID 0000-0002-3767-7205Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

George McDonald ChurchiD· 3 shared Bogdan BudnikiD· 2 shared Alexandru M. PleşaiD· 1 shared Andrew L. JiiD· 1 shared Anna MandinovaiD· 1 shared Anush Chiappino-PepeiD· 1 shared Asaf Ashkenazy-Titelman· 1 shared Azim M. DharaniiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersSynthetic Biology

George McDonald ChurchORCID

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Author profile →

3 papers

Recent·Most cited

Human skin rejuvenation via mRNA

Li Li, Zhengkuan Tang, Xavier Portillo, Rohit Arora, Madeleine Yang, Esther Mintzer, Zhenrui Zhang, Stefano Sol, Fabiana Boncimino, Patrick Han, Michelle Z. Dion, Emery Di Cicco, D.D. Majewski, Asaf Ashkenazy-Titelman, Alexandru M. Pleşa, , George McDonald Church

This paper presents a single-cell atlas of skin aging and identifies ATF3 as a regulator of aging, leading to an mRNA-based treatment that reduces cell senescence and enhances skin rejuvenation.

Journal of Investigative Dermatology · Jul 21, 2026Peer-reviewedSynthetic Biology

Altered Protein Phosphorylation in a Novel Midbrain Organoid Model for Bipolar Disorder

Katharina Meyer, Matthew Woodworth, Maria Carolina Bittencourt Gonçalves, Mi Yue, Hoor Al Jandal, Shad Morton, Michael Lewandowski, Ninning Liu, Eric S. Zigon, Patrick R.J. Fortuna, Mariana García-Corral, Bogdan Budnik, George McDonald Church, Jenny M. Tam

This study develops a midbrain organoid model for bipolar disorder using patient-derived hiPSCs, identifies dysregulated signaling pathways, and shows lithium reverses some abnormalities.

bioRxiv · Apr 1, 2025 · PreprintCell Biology

Preventing escape and malfunction of recoded cells due to tRNA base changes

Anush Chiappino-Pepe, Felix Radford, Bogdan Budnik, Hüseyin Taş, Teresa L. Augustin, Hana M Burgess, Michaël Moret, Azim M. Dharani, Qinmei Zheng, Weicheng Fan, Maksud M Africawala, Shova Thapa, Erkin Kuru, Kamesh Narasimhan, Jorge A. Marchand, , George McDonald Church

The paper shows recoded E. coli can escape faster due to tRNA base changes and introduces kill switches to prevent this.

bioRxiv · Jul 18, 2024 · PreprintSynthetic Biology