Enhanced protein precipitation with ammonia enables rapid, universal extraction of oligonucleotides for bioanalysis
Afrand Kamali, Juili Dilip Shelke, Ethan James Sanford, Michael M. Hayashi, Natthamon Chaisakhon, Robert V. Kolakowski, Sanyogitta Puri, Guangnong Zhang
This paper introduces a method to efficiently extract oligonucleotides from biological samples using ammonia-based protein precipitation, achieving near-complete recovery without costly steps.
ACS Omega · Oct 3, 2025Peer-reviewedBiochemistry