Ethan James Sanford

This paper introduces a method to efficiently extract oligonucleotides from biological samples using ammonia-based protein precipitation, achieving near-complete recovery without costly steps.

The paper identifies a novel phosphorylation motif in Tel1 signaling that expands the understanding of its role in DNA repair and telomere control.

This study identifies how Mec1/ATR kinase controls homologous recombination to suppress gross chromosomal rearrangements through Rad53 and Sgs1 pathways.

The paper identifies Rad53-dependent protein localization changes during replication stress, revealing Mec1-independent activation of Rad53 in yeast.

This study identifies a distinct Mec1/ATR signaling mode triggered by DNA end hyper-resection, showing its role in regulating HR-mediated DNA repair through phosphorylation of the STR complex.

This paper develops a quantitative phosphoproteomic approach to improve reliability and reduce false positives in kinase signaling network analysis, expanding the Mec1 and Tel1 networks.