Satb1 integrates DNA sequence, shape, motif density and torsional stress to differentially bind targets in nucleosome-dense regions.
Rajarshi P. Ghosh, Quanming Shi, Linfeng Yang, Michael P. Reddick, Nikitina Tv, Victor B. Zhurkin, Polly Morrell Fordyce, Timothy J. Stasevich, Howard Y. Chang, William James Greenleaf, Jan Liphardt
This study identifies factors that determine Satb1 binding-site selectivity, showing its preference for nucleosome-dense regions and its mechanosensitive interactions with DNA.
bioRxiv · Oct 26, 2018 · PreprintMolecular Biology