Linfeng Yang

Robust fluorescent labeling and tracking of endogenous non-repetitive genomic loci

This paper develops a method to fluorescently label and track non-repetitive genomic loci in live human cells, showing gene-specific chromatin dynamics independent of transcription.

NuSeT: A Deep Learning Tool for Reliably Separating and Analyzing Crowded Cells

NuSeT improves nuclear segmentation in microscopy images by combining U-Net and RPN with watershed, reducing false positives and handling complex overlaps.

Satb1 integrates DNA sequence, shape, motif density and torsional stress to differentially bind targets in nucleosome-dense regions.

This study identifies factors that determine Satb1 binding-site selectivity, showing its preference for nucleosome-dense regions and its mechanosensitive interactions with DNA.