TDP-43 dysregulation of polyadenylation site selection is a defining feature of RNA misprocessing in ALS/FTD and related disorders
Frederick J. Arnold, Ya Cui, Sebastian Michels, Michael R. Colwin, Cameron M. Stockford, Wenbin Ye, Oliver H. Tam, Sneha Menon, Wendy G. Situ, Kean C. K. Ehsani, Sierra Howard, Molly Hammell, Wei Li, Albert R. La Spada
The paper identifies TDP-43 dysregulation of polyadenylation site selection as a key feature of RNA misprocessing in ALS/FTD and related disorders, linking it to increased tau phosphorylation.
bioRxiv · Jan 22, 2024 · PreprintNeuroscience