Author

Frederick J. Arnold

University of California, IrvineORCID 0000-0003-1927-264XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Albert R. La SpadaiD· 2 shared Sebastian MichelsiD· 2 shared Wei LiiD· 2 shared Alyssa C. WalkeriD· 1 shared Cameron M. StockfordiD· 1 shared Chaorong Chen· 1 shared Cindy V. LyiD· 1 shared Craig L. BennettiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersGenetics

Albert R. La SpadaORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 30, 2026

Characterizing shared and distinctive molecular phenotypes across motor regions in ALS with and without TDP-43 pathology in a veteran cohort

Patricia Hayes Doyle, Shiva Kazempour Dehkordi, Timothy C. Orr…·Miranda E. Orr

The paper identifies senescence-associated molecular states in ALS motor neurons, showing regional and pathological differences but shared senescence features across ALS subtypes.

DOI 10.64898/2026.08.28.747944

humanbulk RNA-seq

𝕏 PostBluesky

GeneticsJournal of Clinical InvestigationPeer-reviewedJun 1, 2026

Multimodal analysis of cell-free DNA identifies epigenetic biomarkers for amyotrophic lateral sclerosis diagnosis and progression

Sebastian Michels, Chaorong Chen, Wolfgang Philipp Ruf…·Albert R. La Spada

This study identifies epigenetic biomarkers in cell-free DNA for ALS diagnosis and progression prediction using methylation analysis.

DOI 10.1172/jci191508

humanDNA methylation

𝕏 PostBluesky

NeurosciencebioRxivPreprintJan 22, 2024

TDP-43 dysregulation of polyadenylation site selection is a defining feature of RNA misprocessing in ALS/FTD and related disorders

Frederick J. Arnold, Ya Cui, Sebastian Michels…·Albert R. La Spada

The paper identifies TDP-43 dysregulation of polyadenylation site selection as a key feature of RNA misprocessing in ALS/FTD and related disorders, linking it to increased tau phosphorylation.

14 citations

humanbulk RNA-seq

𝕏 PostBluesky