Author

Sebastian Michels

Universität UlmORCID 0000-0002-9265-9034Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Albert R. La SpadaiD· 2 shared Frederick J. ArnoldiD· 2 shared Wei LiiD· 2 shared Alyssa C. WalkeriD· 1 shared Cameron M. StockfordiD· 1 shared Chaorong Chen· 1 shared Craig L. BennettiD· 1 shared Daniel Shams· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Albert R. La SpadaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Multimodal analysis of cell-free DNA identifies epigenetic biomarkers for amyotrophic lateral sclerosis diagnosis and progression

Sebastian Michels, Chaorong Chen, Wolfgang Philipp Ruf, M. Madhy Garcia Garcia, Frederick J. Arnold, Zhuoxing Wu, Craig L. Bennett, Daniel Shams, Leslie Michels Thompson, Alyssa C. Walker, Dennis W. Dickson, Leonard Petrucelli, Johannes Dorst, Mercedes Prudencio, Wei Li, Albert R. La Spada

This study identifies epigenetic biomarkers in cell-free DNA for ALS diagnosis and progression prediction using methylation analysis.

Journal of Clinical Investigation · Jun 1, 2026Peer-reviewedGenetics

TDP-43 dysregulation of polyadenylation site selection is a defining feature of RNA misprocessing in ALS/FTD and related disorders

Frederick J. Arnold, Ya Cui, Sebastian Michels, Michael R. Colwin, Cameron M. Stockford, Wenbin Ye, Oliver H. Tam, Sneha Menon, Wendy G. Situ, Kean C. K. Ehsani, Sierra Howard, Molly Hammell, Wei Li, Albert R. La Spada

The paper identifies TDP-43 dysregulation of polyadenylation site selection as a key feature of RNA misprocessing in ALS/FTD and related disorders, linking it to increased tau phosphorylation.

bioRxiv · Jan 22, 2024 · PreprintNeuroscience