Wenbin Ye

The paper identifies TDP-43 dysregulation of polyadenylation site selection as a key feature of RNA misprocessing in ALS/FTD and related disorders, linking it to increased tau phosphorylation.

MEDIPIPE provides an automated pipeline for cfMeDIP-seq data quality control, methylation quantification, and sample aggregation, offering ease of use and scalability for large-scale analysis.

This paper surveys computational methods for predicting polyadenylation sites from DNA sequences, bulk RNA-seq, and single-cell RNA-seq data, discussing challenges and future directions.

The paper introduces scLAPA, a toolkit that improves cell-cell association and clustering in scRNA-seq by integrating gene expression and alternative polyadenylation data.