Dual recognition of negative charge by pleckstrin homology (PH) domains
Christopher K Ng, James W. Murphy, Jeannine M. Mendrola, Michael Sarullo, Steven E. Stayrook, Kathryn M. Ferguson, Mark A. Lemmon
The paper shows PH domains bind both phosphoinositides and negatively charged protein regions, expanding their regulatory roles beyond membrane targeting.
bioRxiv · Sep 22, 2026 · PreprintBiochemistry