Author

Mark A. Lemmon

Yale UniversityORCID 0000-0002-3379-5319Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Kumar Dilip AshtekariD· 2 shared Yuko TsutsuiiD· 2 shared Christopher K NgiD· 1 shared Debdas DhabaliD· 1 shared Hrishabh Singh· 1 shared James W. MurphyiD· 1 shared Jeannine M. MendrolaiD· 1 shared Kathryn M. FergusoniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

Kumar Dilip AshtekarORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dual recognition of negative charge by pleckstrin homology (PH) domains

Christopher K Ng, James W. Murphy, Jeannine M. Mendrola, Michael Sarullo, Steven E. Stayrook, Kathryn M. Ferguson, Mark A. Lemmon

The paper shows PH domains bind both phosphoinositides and negatively charged protein regions, expanding their regulatory roles beyond membrane targeting.

bioRxiv · Sep 22, 2026 · PreprintBiochemistry

EGFR and tyrosine kinase inhibitor interactions probed by hydrogen-deuterium exchange and mass spectrometry (HDX-MS)

Kumar Dilip Ashtekar, Mark A. Lemmon, Yuko Tsutsui

This study uses HDX-MS to analyze EGFR dynamics upon TKI binding, revealing inhibitor-dependent structural changes that correlate with side effects and covalent inhibitor selectivity.

bioRxiv · Oct 14, 2024 · PreprintBiophysics

Coupled Solvent and Protein Dynamics Confer Differences in Exon-19 Deletion Mutants of the Epidermal Growth Factor Receptor Kinase

Keshav Patil, Debdas Dhabal, Kumar Dilip Ashtekar, Yuko Tsutsui, Krishna Suresh, Hrishabh Singh, Mark A. Lemmon, Ravi Radhakrishnan

This study identifies two mutation profiles in EGFR Exon-19 deletions that correlate with differential TKI sensitivity through analysis of conformational dynamics and solvent interactions.

bioRxiv · Oct 4, 2024 · PreprintBiophysics