Mechanism of USP21 autoinhibition and histone H2AK119 deubiquitination
Sanim Rahman, Michael Thomas Morgan, Chad W. Hicks, Alexander Gwizdala, Cynthia Wolberger
This study determines the structure of USP21 bound to H2AK119ub and identifies phosphorylation-regulated autoinhibition as a mechanism for its activity regulation.
bioRxiv · Apr 17, 2025 · PreprintBiophysics