Chad W. Hicks

The paper uses cryo-EM to analyze lambda-6 light chain amyloid structures from different organs and patients, revealing structural diversity and potential interactions with collagen-VI.

The paper shows that inhibiting the CoREST complex with corin alters RNA splicing, increases neoantigen expression, and enhances tumor immunity in melanoma.

The paper reports a cryo-EM structure of cardiac AL-224L amyloid and identifies shared structural features across {lambda}6-LC amyloid folds.

This study determines the structure of USP21 bound to H2AK119ub and identifies phosphorylation-regulated autoinhibition as a mechanism for its activity regulation.

The paper reports cryo-EM structures of Haspin kinase bound to a nucleosome, revealing its unique DNA supergroove binding mechanism for phosphorylating H3T3.

This study reveals that H2BK120ub blocks the nucleosome acidic patch, preventing protein binding, while H2AK119ub does not, highlighting distinct roles of these ubiquitinations in chromatin regulation.