Cynthia Wolberger

The paper shows that FACT facilitates Ubp10 release from nucleosomes after H2B deubiquitination, revealing release as the rate-limiting step for Ubp10 turnover.

This paper benchmarks AlphaFold3's ability to predict structures of chromatin complexes, finding it excels at histone interactions but struggles with DNA-binding factors.

This study determines the structure of USP21 bound to H2AK119ub and identifies phosphorylation-regulated autoinhibition as a mechanism for its activity regulation.

The paper reports cryo-EM structures of Haspin kinase bound to a nucleosome, revealing its unique DNA supergroove binding mechanism for phosphorylating H3T3.

This study reveals that H2BK120ub blocks the nucleosome acidic patch, preventing protein binding, while H2AK119ub does not, highlighting distinct roles of these ubiquitinations in chromatin regulation.

The paper reports the cryo-EM structure of a COMPASS subcomplex bound to a ubiquitinated nucleosome, revealing how H2B ubiquitination stimulates H3K4 methylation.

The paper shows that replacing the catalytic cysteine in DUBs with alanine increases their ubiquitin binding affinity, potentially causing unintended physiological effects.