Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism
Lauren M. Reynolds, Giovanni Hernández, Del MacGowan, Christina Popescu, Dominique Nouel, Santiago Cuesta, Samuel Burke, Katherine E. Savell, Janet Mengyi Zhao, Jose M. Restrepo-Lozano, Michel Giroux, Sonia Ancoli Israel, Taylor Orsini, Susan He, Michael Wodzinski, , Cecilia Flores
This study shows that amphetamine exposure in adolescence causes sex-specific changes in dopamine axon growth via Netrin-1/DCC signaling, with male mice showing increased vulnerability.
Nature Communications · Jul 7, 2023Peer-reviewedNeuroscience