Giovanni Hernández

This study shows that adolescent amphetamine exposure causes sex-specific changes in mesolimbic dopamine axons and PFC dopamine transporter expression in adulthood, with males showing increased vulnerability to drug effects.

The paper identifies GluN2C NMDA receptors in the VTA as critical for relaying reward signals from DR stimulation, showing reduced reward with GluN2C downregulation and increased reward with NMDA antagonist.

This study shows that amphetamine exposure in adolescence causes sex-specific changes in dopamine axon growth via Netrin-1/DCC signaling, with male mice showing increased vulnerability.