Lipophilic compounds restore wt function of neurodevelopmental-associated KCNQ3 mutations.
Michaela A. Edmond, Andy Hinojo-Perez, Mekedlawit Efrem, Yi-Chun Lin, Iqra Shams, Sebastien Hayoz, Alicia de la Cruz, Marta E. Perez Rodriguez, Maykelis Diaz-Solares, Derek M. Dykxhoorn, Yun Lyna Luo, Rene Barro-Soria
The paper investigates how two KCNQ3 mutations impair channel function and shows that polyunsaturated fatty acids can restore wild-type function in these mutations.
bioRxiv · Mar 13, 2024 · PreprintBiophysics