Yun Luo

This study shows Yoda1 agonizes PIEZO2 with efficacy similar to PIEZO1 but distinct effects on calcium influx and inactivation kinetics.

This paper introduces BIN-PU, a PU learning framework for predicting bacterial protein-compound interactions using only positive samples, showing improved performance over existing methods.

CholBindNet predicts cholesterol binding sites on membrane proteins using interpretable deep learning, outperforming existing models and aligning with molecular dynamics simulations.

This paper optimizes a coarse-grained lipid model for large-scale membrane protein simulations and demonstrates its application to study PIEZO-induced membrane deformation.

This study reveals how tension-induced structural changes in PIEZO2 channels lead to pore opening and ion conduction through dynamic conformational motions.

This study uses molecular dynamics simulations to quantify how voltage-dependent free energy barriers in ion-nanopore systems lead to current rectification, showing it depends on ion type and pore polarity.

This study shows that mammalian PIEZO1 and PIEZO2 channels rectify chloride currents inwardly, while sodium currents show little rectification, indicating voltage-dependent anion permeation.

The paper investigates how two KCNQ3 mutations impair channel function and shows that polyunsaturated fatty acids can restore wild-type function in these mutations.

The paper shows that connexin hemichannels can transport molecules independently of ion conduction, challenging the conventional view of their function.

The paper identifies NA-184, a selective calpain-2 inhibitor, and shows its neuroprotective effects in traumatic brain injury models.