Genetic & Genomic MedicineNature CommunicationsPeer-reviewed
Estimating Disorder Probability Based on Polygenic Prediction Using the BPC Approach
Emil Uffelmann, Cathryn M. Lewis, Andrew Mark McIntosh…·Wouter J. Peyrot
The paper introduces the BPC approach to improve polygenic score calibration for binary disorders, achieving better calibration than existing methods in simulated and empirical data.