Oligodendrocytes may provide the extra density of α-synuclein filaments from multiple system atrophy
Dongqi Zhang, Magdalena Matic, Airi Tarutani, Alexey G Murzin, Melissa Huang, Jennifer A McDonald, Taxiarchis Katsinelos, Patrick C Cullinane, Kazuko Hasegawa, Zane Jaunmuktane, Masato Hasegawa, Nadia Stefanova, Michel Goedert, Sjors Scheres
The paper investigates how oligodendrocytes contribute to the formation of α-synuclein filaments in multiple system atrophy by comparing seeded aggregation in different cell types.
bioRxiv · Nov 3, 2026 · PreprintNeuroscience