Author

Kazuko Hasegawa

National Sagamihara Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 6 Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Assay:protein structure· 3 Research Focus:protein structure prediction· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Sjors H. W. ScheresiD· 6 shared Masato HasegawaiD· 5 shared Michel GoedertiD· 5 shared Shigeo MurayamaiD· 5 shared Airi TarutaniiD· 4 shared Manuel SchweighauseriD· 4 shared Mari YoshidaiD· 4 shared Alexey G. Murzin· 3 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersNeuroscience

Sjors H. W. ScheresORCID

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Oligodendrocytes may provide the extra density of α-synuclein filaments from multiple system atrophy

Dongqi Zhang, Magdalena Matic, Airi Tarutani, Alexey G Murzin, Melissa Huang, Jennifer A McDonald, Taxiarchis Katsinelos, Patrick C Cullinane, Kazuko Hasegawa, Zane Jaunmuktane, Masato Hasegawa, Nadia Stefanova, Michel Goedert, Sjors Scheres

The paper investigates how oligodendrocytes contribute to the formation of α-synuclein filaments in multiple system atrophy by comparing seeded aggregation in different cell types.

bioRxiv · Nov 3, 2026 · PreprintNeuroscience

Prion-like transmission of human tau strains in the mouse brain

Sofia Lövestam, Aki Shimozawa, Airi Tarutani, Reiko Ohtani, Masami Masuda‐Suzukake, Kazuko Hasegawa, Andrew Robinson, Yuko Saito, Shigeo Murayama, Mari Yoshida, Hisaomi Suzuki, Mitsumoto Onaya, Masato Hasegawa, Michel Goedert, Sjors H. W. Scheres

This study demonstrates that tau filaments from Alzheimer's and corticobasal degeneration patients can seed the formation of structurally identical mouse tau filaments, supporting the prion-like transmission hypothesis.

Nature · Sep 30, 2026Peer-reviewedNeuroscience

Widespread Distribution of α-Synuclein Oligomers in LRRK2-related Parkinson's Disease

Hiroaki Sekiya, Lukas Franke, Yuki Hashimoto, Mariko Takata, Katsuya Nishida, Naonobu Futamura, Kazuko Hasegawa, Hisatomo Kowa, Owen A. Ross, Pamela J. McLean, Tatsushi Toda, Zbigniew K. Wszołek, Dennis W. Dickson

This study examines the distribution of α-synuclein oligomers in LRRK2-related Parkinson's disease, finding a negative correlation between oligomers and Lewy-related pathology.

Acta Neuropathologica · May 2, 2025Peer-reviewedNeuroscience

Genome-wide association study identifies a new susceptibility locus in PLA2G4C for Multiple System Atrophy.

Yasuo Nakahara, Jun Mitsui, Hidetoshi Date, Kristine Joyce L. Porto, Yasuhiro Hayashi, Atsushi Yamashita, Yoshio Kusakabe, Takashi Matsukawa, Hiroyuki Ishiura, Tsutomu Yasuda, Atsushi Iwata, Jun Goto, Yaeko Ichikawa, Yoshio Momose, Yuji Takahashi, , Shoji Tsuji

This study identifies a new susceptibility locus, PLA2G4C, for Multiple System Atrophy through a genome-wide association study and functional analysis of a risk variant.

medRxiv · May 2, 2023 · PreprintGenetic & Genomic Medicine

Cryo-EM structures of α-synuclein filaments from Parkinson's disease and dementia with Lewy bodies

Yang Yang, Yang Shi, Manuel Schweighauser, Xianjun Zhang, Abhay Kotecha, Alexey G. Murzin, Holly J. Garringer, Patrick W. Cullinane, Yuko Saito, Tatiana Foroud, Thomas T. Warner, Kazuko Hasegawa, Rubén Vidal, Shigeo Murayama, Tamás Révész, , Michel Goedert

The paper reports cryo-EM structures of α-synuclein filaments from Parkinson's disease, PD dementia, and dementia with Lewy bodies, showing they are composed of a single protofilament distinct from those in multiple system atrophy.

bioRxiv · Jul 12, 2022 · PreprintNeuroscience

Age-dependent formation of TMEM106B amyloid filaments in human brain

Manuel Schweighauser, Diana Arseni, Mehtap Bacioglu, Melissa Huang, Sofia Lövestam, Yang Shi, Yang Yang, Wenjuan Zhang, Abhay Kotecha, Holly J. Garringer, Rubén Vidal, Grace I. Hallinan, Kathy L. Newell, Airi Tarutani, Shigeo Murayama, , Sjors H. W. Scheres

This study identifies age-dependent formation of TMEM106B amyloid filaments in human brains using cryo-EM, showing they appear in older individuals but not younger ones.

Nature · Mar 28, 2022Peer-reviewedNeuroscience

Seeded assembly in vitro does not replicate the structures of α-synuclein filaments from multiple system atrophy

Sofia Lövestam, Manuel Schweighauser, Tomoyasu Matsubara, Shigeo Murayama, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, Mari Yoshida, Airi Tarutani, Masato Hasegawa, Michel Goedert, Sjors H. W. Scheres

FEBS Open Bio · Feb 6, 2021Peer-reviewedMolecular Biology

Structures of α-synuclein filaments from multiple system atrophy

Manuel Schweighauser, Yang Shi, Airi Tarutani, Fuyuki Kametani, Alexey G. Murzin, Bernardino Francesco Ghetti, Tomoyasu Matsubara, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, Shigeo Murayama, Mari Yoshida, Masato Hasegawa, Sjors H. W. Scheres, Michel Goedert

This study determines the structure of α-synuclein filaments in multiple system atrophy using cryo-EM, revealing distinct filament types and conformers that differ from in vitro assemblies.

Nature · May 27, 2020Peer-reviewedNeuroscience