A paradoxical relationship between mitochondrial calcium regulation and retinal ganglion cell degeneration after axon damage
Sean McCracken, Minglei Zhao, Kyler Squirrell, Chengzhi Zhao, Saman Behboodi Tanourlouee, Michelle Aum, Philip Raymond Williams
This study shows that higher mitochondrial calcium levels predict retinal ganglion cell survival after optic nerve injury, but reducing mitochondrial calcium increases survival, revealing a paradoxical relationship.
bioRxiv · May 15, 2026 · PreprintNeuroscience