Minglei Zhao

In a mouse branch retinal vein occlusion model, retinal ganglion cells die progressively over 14 days. α-RGCs and F-RGCs are lost fastest, and TBR2-positive intrinsically photosensitive RGCs survive best.

This study shows that higher mitochondrial calcium levels predict retinal ganglion cell survival after optic nerve injury, but reducing mitochondrial calcium increases survival, revealing a paradoxical relationship.

This paper develops a conformation-specific antibody, K27-IgG, to detect K27-linked polyubiquitin and identifies DNAJB1 as a reader and UBE2Q1 as a writer for this ubiquitin chain type.

This study reveals how prestin translates membrane tension into charge and motor movement during sound-evoked vibrations through structural analysis and complementary experiments.

This study investigates how Zn2+ activates PaMsbA, an ABC transporter in Pseudomonas aeruginosa, by enhancing its ATPase activity and promoting dimerization.

The paper characterizes HLA-B*73:01, revealing its unique peptide binding motif, restricted peptidome, and distinct interaction with KIR2DL2, suggesting evolutionary advantages in pathogen resistance.

This study determines the structure of the human vault cage with PARP4 and NAD+, revealing binding interfaces and NAD+ pockets, and shows proteomics differences in PARP4-depleted vaults.

The paper reports the cryo-EM structure of full sACE dimer and uses MD simulations to study its conformational dynamics and domain-specific behavior.

The paper introduces DeepTracer-2.0, an AI pipeline that automatically models protein-DNA/RNA complexes from cryo-EM maps, improving accuracy and efficiency in macromolecular structure prediction.