AR-V7 Utilizes a Noncanonical Nuclear Localization Signal to Sustain Androgen-Independent Nuclear Import and Signaling
Urko del Castillo, Naira Essam Abou-Ghali, Colin S. Burdette, Michelle Naidoo, CheukMan Cherie Au, Kiran Kumari Sahu, Xuanrong Chen, Xi Kathy Zhou, Jacob Geri, Paraskevi Giannakakou
This study identifies a noncanonical nuclear localization signal in AR-V7 that enables androgen-independent nuclear import and transcriptional activity, revealing distinct vulnerabilities for targeting AR-V7 signaling.
bioRxiv · Sep 24, 2026 · PreprintCancer Biology